Centre for Cellular and Molecular Biology (CCMB) Hyderabad has found an innovative way to hinder the process of bacterial growth. It can lead to the development of new antibiotics that can address new resistance and help us to cure the disease.
CCMB Director Dr Rakesh Mishra while speaking to media person he said that the discovery shows how cell-wall formation can be a pause in the beginning stage itself, and this can help combat harmful bacteria effectively in the wake of several strains of bacteria developing resistance to antibiotics.
Senior Researcher Dr Manjula Reddy leading the team had brought an outstanding contribution for this new mechanism, which focused on ‘scissors’ which changed the existing thread in the cell wall to insert new material for bacterial growth which blocks the cell wall growth.
The cell wall is a principal to bacterial development and division. Its formations include a gathering of proteins, each assuming an alternate role, together making a mesh. A few proteins cleave the strands of the mesh, and after that, the second set of proteins fasten together the isolated strands with new material. Conventional antibiotics target this last phase of cell-wall synthesis, Dr Mishra clarified.
Dr Reddy’s “one-of-its-kind” revelation can possibly build up another class of anti-microbials to battle microorganisms, which is the reason for various diseases, the CCMB chief included. Dr Reddy said they isolated an enzyme — Endo Peptizyde which helps in the amalgamation of the bacterial cell wall, therefore helping the bacteria multiply and make antibodies in the human immune system.
The result of the whole research will be published in the science journal ‘Proceedings of National Academy of Sciences (PNAS), USA’