Mumbai, December 4, 2018:In pre-clinical trials, New Zealand’s University of Otago researchers have discovered a promising new therapy that has the potential to be used clinically for improving survival rates for people who suffer a heart attack.
The researchers from HeartOtago – a group of cardiovascular researchers and clinicians located at the University and Dunedin Hospital – the Brain Health Research Centre and Centre for Neuroendocrinology, found blocking specific oxytocin cells within the brain after a heart attack dramatically improved survival outcome. Their research was recently published in biological sciences journalCommunications Biology.
“Our results strongly advocate blockade of oxytocin cells as a promising emerging therapy for the acute management of an acute heart attack,”Associate Professor Daryl Schwenkesays.
An acute heart attack, or myocardial infection, is one of the most common causes of death in industrialised societies. Often death can occur within the first few hours following a heart attack due to a dangerous over-stimulation of nerves that control heart function.
Associate Professor Schwenkeexplains that when a person has a heart attack the brain thinks the heart is damaged, so it“speaks a lot louder to the heart”.
“If you’ve just had a heart attack, the one thing the heart doesn’t need is to be told to work harder. So, we need to try and create an environment where the heartfeels less stressed after a heart attack in order to try and restore its natural function.”
The reason why the nerves that control heart function become over-activated has remained unclear. However,Associate Professor Schwenkeand his colleaguesDr Ranjan Roy, Dr Rachael AugustineandProfessor Colin Brown, have recently identified a distinct region within the brain containing oxytocin cells that become “switched on” immediately after an acute heart attack.
Although oxytocin is traditionally associated with uterine contractions during labour and breastfeeding, some of these cells also modulate the nerves that control the heart.
“When we experimentally blocked these oxytocin cells after a heart attack, we found that the heart nerves did not become activated and, remarkably, survival and outcome were dramatically improved,”Associate Professor Schwenkesays.
This exciting scientific breakthrough is still currently in the experimental stages. However, Associate Professor Schwenke and his colleagues are optimistic that a new and novel pharmacological drug targeting the oxytocin cells will one day be eligible for advancing the concept to clinical trials.
“We are very hopeful that this will have long-term benefits for all cardiovascular patients in the future,”Associate Professor Schwenkesays.
This video is available for use with credit to the University of Otago-https://youtu.be/nIZvONcQxyg