According to a new research study by the Department of Microbiology of Mount Sinai School of Medicine; have shown that women who have previously got infected with dengue virus may be at a risk for increased damage to their fetuses and placentas following Zika virus infection during pregnancy. The research indicates that there is a possible mechanism for the enhancement of Zika virus progression during pregnancy in an animal model.
Results of the study, “Dengue virus immunity increases Zika virus-induced damage during pregnancy,” were published in the February issue of Immunity, a journal published by Cell Press.
“Our data demonstrate that antibodies generated from a previous dengue virus infection can enhance the severity of Zika virus infection during pregnancy,” said Dr. Lim. “Our research may explain the high rate of microcephaly and birth defects observed in the recent Zika virus outbreak in South America.”
Other key authors on the study include Florian Krammer, PhD, Associate Professor of Microbiology, and Adolfo Garcia-Sastre, PhD, Director of Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai.